If you encounter issues during the creation or booting process, check these common configurations:

Map the backup partitions to your target internal drive, then click and Finish to begin the overwrite. Fixing Windows Boot Failures

If you choose to compile the rescue media into an ISO file rather than writing directly to a USB, software like Rufus or Ventoy will help you make it bootable later. Step-by-Step: Creating the Macrium Reflect ISO