Do not prestige the moment it becomes available. Wait until your progress slows to a crawl so you secure a much larger multiplier bonus.

Progression slows down significantly at the and Ultra Leek stages, making prestiging critical.

This comprehensive guide details optimal production structures, layout ratios, and progression priorities for the latest version of the game. The End-Game Blueprint: Atomic Leek Setup

Here is the breakdown of the optimal layout strategy in the current update: