It is natively DRM-free on GOG and requires no disk on Steam.
The best solution is purchasing the Titan Quest Anniversary Edition on Steam or GOG. It combines the base game and expansion, eliminates all CD checks, and works perfectly on Windows 10/11. titan quest immortal throne 1.30 no cd crack
Version was the final official patch for the original Titan Quest (2006) and served as the baseline for the Immortal Throne It is natively DRM-free on GOG and requires no disk on Steam